Publications (* co-first author)
Jiang F*, Liu J-J*, Osuna BA*, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J & Doudna JA.(2019) Temperature-responsive competitive inhibition of CRISPR-Cas9. Molecular Cell, 73(3):601-610.e5. Epub 2018 Dec 27. PMID: 30595438
Park HM, Liu H, Wu J, Chong A, Mackley V, Fellmann C, Rao A, Jiang F, Chu H, Murthy N, Lee K. (2018) Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. Nature Communication, 17;9(1):3313. PMID: 30120228
Shin J*, Jiang F*, Liu JJ*, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. (2017) Disabling Cas9 by an anti-CRISPR DNA mimic. Science Advances, 3(7):e1701620. PMID: 28706995
Jiang F, Doudna JA. (2017) CRISPR-Cas9 Structures and Mechanisms. Annual Review of Biophysics, 46:505-529. doi: 10.1146/annurev-biophys-062215-010822. PMID: 28375731
Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang W, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N. (2017) Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nature Biomedical Engineering, 1:889-901. PMID: 29805845
Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. (2016) Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife, 5:e13450. PMID: 27130520
Jiang F*, Taylor DW*, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. (2016) Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science, 351(6275):867-71. PMID: 26841432
Liu HM, Jiang F, Loo YM, Hsu S, Hsiang TY, Marcotrigiano J, Gale M Jr. (2016) Regulation of retinoic acid inducible Gene-I (RIG-I) activation by the histone deacetylase 6. EBioMedicine, 9:195–206. PMID: 27372014
Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, Marcotrigiano J. (2016) Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proceedings of the National Academy of Sciences USA, 113(3):596-601. PMID: 26733676
Jiang F, Zhou K, Ma L, Gressel S, Doudna JA. (2015) A Cas9-guide RNA complex preorganized for target DNA recognition. Science, 348(6242):1477-81. PMID: 26113724
Jiang F, Doudna JA. (2015) The Structural Biology of CRISPR-Cas Systems. Current Opinion in Structural Biology, 30:100-11. PMID: 25723899
Ramanathan A, Devarkar SC, Jiang F, Miller MT, Khan AG, Marcotrigiano J, Patel SS. (2015) The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection. Nucleic Acids Research, 44(2):896-909. PMID: 26612866
Jinek M*, Jiang F*, Taylor DW*, Sternberg SH*, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. (2014) Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, 343(6176):1247997. PMID: 24505130
Jiang F*, Ramanathan A*, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J. (2011) Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature, 479(7373):423-7. PMID: 21947008
Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M Jr. (2008) Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature, 454(7203):523-7. PMID: 18548002
Zhao Q*, Qin L*, Jiang F, Wu B, Yue W, Xu F, Rong Z, Yuan H, Xie X, Gao Y, Bai C, Bartlam M, Pei X, Rao Z. (2007) Structure of human spindlin1: tandem tudor-like domains for cell cycle regulation. The Journal of Biological Chemistry, 282(1): 647-56. PMID: 17082182
Jiang F, Zhao Q, Qin L, Pang H, Pei X, Rao Z. (2006) Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein. Protein and Peptide Letters, 13(2): 203-5. PMID: 16472086
Pang H, Liu Y, Han X, Xu Y, Jiang F, Wu D, Kong X, Bartlam M, Rao Z. (2004) Protective humoral responses to severe acute respiratory syndrome-associated coronavirus: implications for the design of an effective protein-based vaccine. Journal of General Virology, 85(10):3109-13. PMID: 15448374