Publications (* co-first author)




Jiang F*, Liu J-J*, Osuna BA*, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J & Doudna JA.(2019) Temperature-responsive competitive inhibition of CRISPR-Cas9. Molecular Cell, 73(3):601-610.e5. Epub 2018 Dec 27. PMID: 30595438





Park HM, Liu H, Wu J, Chong A, Mackley V, Fellmann C, Rao A, Jiang F, Chu H, Murthy N, Lee K. (2018) Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivoNature Communication, 17;9(1):3313. PMID: 30120228




Shin J*, Jiang F*, Liu JJ*, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. (2017) Disabling Cas9 by an anti-CRISPR DNA mimic. Science Advances, 3(7):e1701620. PMID: 28706995  

Jiang F, Doudna JA. (2017) CRISPR-Cas9 Structures and MechanismsAnnual Review of Biophysics, 46:505-529. doi: 10.1146/annurev-biophys-062215-010822. PMID: 28375731

Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang W, Lan F, Bray NL, Li S, Corn JE, Kataoka K, Doudna JA, Conboy I, Murthy N. (2017) Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nature Biomedical Engineering, 1:889-901. PMID: 29805845




Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. (2016) Nucleosome breathing and remodeling constrain CRISPR-Cas9 functionElife, 5:e13450. PMID: 27130520 


Jiang F*, Taylor DW*, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. (2016) Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavageScience, 351(6275):867-71. PMID: 26841432 


Liu HM, Jiang F, Loo YM, Hsu S, Hsiang TY, Marcotrigiano J, Gale M Jr. (2016) Regulation of retinoic acid inducible Gene-I (RIG-I) activation by the histone deacetylase 6EBioMedicine, 9:195–206. PMID: 27372014 


Devarkar SC, Wang C, Miller MT, Ramanathan A, Jiang F, Khan AG, Patel SS, Marcotrigiano J. (2016) Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-IProceedings of the National Academy of Sciences USA, 113(3):596-601. PMID: 26733676




Jiang F, Zhou K, Ma L, Gressel S, Doudna JA. (2015) A Cas9-guide RNA complex preorganized for target DNA recognition. Science, 348(6242):1477-81. PMID: 26113724 


Jiang F, Doudna JA. (2015) The Structural Biology of CRISPR-Cas SystemsCurrent Opinion in Structural Biology, 30:100-11. PMID: 25723899


Ramanathan A, Devarkar SC, Jiang F, Miller MT, Khan AG, Marcotrigiano J, Patel SS. (2015) The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selectionNucleic Acids Research, 44(2):896-909. PMID: 26612866 



Jinek M*, Jiang F*, Taylor DW*, Sternberg SH*, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. (2014) Structures of Cas9 endonucleases reveal RNA-mediated conformational activationScience, 343(6176):1247997. PMID: 24505130 




Jiang F*, Ramanathan A*, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J. (2011) Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature, 479(7373):423-7. PMID: 21947008 


Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M Jr. (2008) Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature, 454(7203):523-7. PMID: 18548002


Zhao Q*, Qin L*, Jiang F, Wu B, Yue W, Xu F, Rong Z, Yuan H, Xie X, Gao Y, Bai C, Bartlam M, Pei X, Rao Z. (2007) Structure of human spindlin1: tandem tudor-like domains for cell cycle regulationThe Journal of Biological Chemistry, 282(1): 647-56. PMID: 17082182


Jiang F, Zhao Q, Qin L, Pang H, Pei X, Rao Z. (2006) Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein.  Protein and Peptide Letters, 13(2): 203-5.  PMID: 16472086


Pang H, Liu Y, Han X, Xu Y, Jiang F, Wu D, Kong X, Bartlam M, Rao Z. (2004) Protective humoral responses to severe acute respiratory syndrome-associated coronavirus: implications for the design of an effective protein-based vaccineJournal of General Virology, 85(10):3109-13. PMID: 15448374








All content © 2019, Jiang Lab

  • LinkedIn Social Icon